A review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy
… 10) is the fourth-generation EGFR inhibitor obtained by high-throughput screening (HTS)
strategy from a library of 2.5 million compounds at 1 µM ATP concentration. EAI001 57 is a …
strategy from a library of 2.5 million compounds at 1 µM ATP concentration. EAI001 57 is a …
Epidermal growth factor receptor (EGFR) involvement in epithelial‐derived cancers and its current antibody‐based immunotherapies
M London, E Gallo - Cell biology international, 2020 - Wiley Online Library
… epithelial-derived tumors, and associated with poor prognosis and survival in cancer patients.
Here, we discuss in detail the role of EGFR in specific epithelial-derived … -EGFR therapies. …
Here, we discuss in detail the role of EGFR in specific epithelial-derived … -EGFR therapies. …
[PDF][PDF] Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors
… epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors… tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human …
receptors… tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human …
Development of dual inhibitors targeting epidermal growth factor receptor in cancer therapy
L Tan, J Zhang, Y Wang, X Wang, Y Wang… - Journal of Medicinal …, 2022 - ACS Publications
… Epidermal growth factor receptor (EGFR) is of great … Currently, third-generation inhibitors
of EGFR, especially … d]pyrimidine derivative possessed more potent EGFR inhibition …
of EGFR, especially … d]pyrimidine derivative possessed more potent EGFR inhibition …
[HTML][HTML] Implementing anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer: challenges and future perspectives
E Martinelli, D Ciardiello, G Martini, T Troiani… - Annals of …, 2020 - Elsevier
… EGFR inhibition in second-line therapy of mCRC patients after progression from first-line
treatment … Third-line treatment in patients with RAS WT mCRC who obtained a PR/CR in first …
treatment … Third-line treatment in patients with RAS WT mCRC who obtained a PR/CR in first …
Natural tyrosine kinase inhibitors acting on the epidermal growth factor receptor: Their relevance for cancer therapy
Y Liang, T Zhang, J Zhang - Pharmacological Research, 2020 - Elsevier
… As the significant approach in the cancer targeted therapy, synthetic EGFR-TKIs have been
… conclusion, EGFR-TKIs are the standard first-line treatment to patients with advanced EGFR-…
… conclusion, EGFR-TKIs are the standard first-line treatment to patients with advanced EGFR-…
[HTML][HTML] Efficacy and safety of epidermal growth factor receptor (EGFR) inhibitors plus antiangiogenic agents as first-line treatments for patients with advanced EGFR …
F Chen, N Chen, Y Yu, J Cui - Frontiers in Oncology, 2020 - frontiersin.org
… the use of EFGR-TKIs plus angiogenesis inhibitors as a first-line therapy for NSCLC. Mesh
and entry … prescribed drugs were checked to further derive qualified publications. Further, we …
and entry … prescribed drugs were checked to further derive qualified publications. Further, we …
Epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC)
C O'Leary, H Gasper, KB Sahin, M Tang, A Kulasinghe… - Pharmaceuticals, 2020 - mdpi.com
… of single-agent EGFR inhibitors in the first-line setting. Similarly, adjuvant EGFR inhibitors, are
… Combining existing and new treatments with EGFR-targeted therapy is a potential strategy …
… Combining existing and new treatments with EGFR-targeted therapy is a potential strategy …
Molecular targeting of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR)
… applications in the detection and treatment of cancer. This … show limited wild-type EGFR
inhibition. Therefore these drugs do … derivatives and used in tumor imaging and treatment [173]. …
inhibition. Therefore these drugs do … derivatives and used in tumor imaging and treatment [173]. …
Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders
… the 9–14 months of treatment. (10−13) To overcome the resistance, a number of the
second-generation EGFR inhibitors targeting EGFR harboring T790M activating mutation have been …
second-generation EGFR inhibitors targeting EGFR harboring T790M activating mutation have been …